Human papillomavirus-like particles vaccine efficiently produced in a non-fermentative system based on insect larva
نویسندگان
چکیده
منابع مشابه
Human papillomavirus-like particles vaccine efficiently produced in a non-fermentative system based on insect larva.
Alicia Fernández-San Millán, Silvia Gómez-Sebastián, María C. Nuñez, Jon Veramendi and José M. Escribano* Instituto de Agrobiotecnología (Universidad Pública de Navarra-CSICGobierno de Navarra), Campus Arrosadía, 31006 Pamplona, Spain Alternative Gene Expression S.L. (ALGENEX). Centro empresarial Parque Científico y Tecnológico de la Universidad Politécnica de Madrid Campus de Montegancedo, 282...
متن کاملHuman Papillomavirus Type16- L1 VLP Production in Insect Cells
Objective(s): Infection by high-risk papillomavirus is regarded as the major risk factor in the development of cervical cancer. Recombinant DNA technology allows expression of the L1 major capsid protein of HPV in different expression systems, which has intrinsic capacity to self-assemble into viral-like particles (VLP). VLPS are non-infectious, highly immunogenic and can elicit neutralizing...
متن کاملEffective Chikungunya Virus-like Particle Vaccine Produced in Insect Cells
The emerging arthritogenic, mosquito-borne chikungunya virus (CHIKV) causes severe disease in humans and represents a serious public health threat in countries where Aedes spp mosquitoes are present. This study describes for the first time the successful production of CHIKV virus-like particles (VLPs) in insect cells using recombinant baculoviruses. This well-established expression system is ra...
متن کاملBacterially Produced Recombinant Influenza Vaccines Based on Virus-Like Particles
Although current influenza vaccines are effective in general, there is an urgent need for the development of new technologies to improve vaccine production timelines, capacities and immunogenicity. Herein, we describe the development of an influenza vaccine technology which enables recombinant production of highly efficient influenza vaccines in bacterial expression systems. The globular head d...
متن کاملIn vitro gene transfer using human papillomavirus-like particles.
Recombinant papillomavirus-like particles have recently been shown to be highly effective for the prevention of papillomavirus infections and associated tumors, and a virus-like particle-based vaccine against the most prevalent HPV causing genital infection in humans will be developed in the near future. Another use of these virus-like particles may lie in gene therapy and DNA immunization. We ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Protein Expression and Purification
سال: 2010
ISSN: 1046-5928
DOI: 10.1016/j.pep.2010.06.009